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Real DOCTOR reacts to CELLS AT WORK! // Episode 2 // “Scrape Wound”

Hi, I’m Ed Hope, a junior doctor in the UK and welcome to my channel, Sick Notes where I explained medical things in simple terms like the other week I looked at the medical anime Cells at Work and not only did the show blow me away but your response to the video did as well over a million views in a few days guys thank you so, so much for all the support So it’s only fair that I check out episode number two of Cells at Work [anime plays – Japanese audio] So, we’re following our red blood cell again as she carries the oxygen around the body and she’s lost, like she spent most of the first episode and we met them briefly before but we get properly introduced to the very cute platelets The medical term for them is the thrombocytes “THROMBO” because they’re involved in creating a thrombus- That’s what we call a blood clot – and CYTE is a name we give to any mature cell [Japanese audio continues] So in this depiction they’re little kids and this ties in because platelets are actually very tiny about a third of the size of a red blood cells That’s because their job is to really plug the small gaps when a thrombus forms. And this episode is called a scrape wound so we’re probably going to find out all about how they work and everything they’re carrying as well Aw, I like that the platelet calls the red blood cell “Big Sister” because this is entirely accurate because the two are related in the kind of family tree of blood cells So they share the same ancestry of cells all produced in the center of the bones, what we call the bone marrow in a process we call hematopoiesis Quite literally means “production of blood” So we have our stems cells in the bone marrow You’ve probably heard of these in lots of medical research because they’ve got the ability to turn into lots of different cell types. One of these cell types is the myeloid progenitor cells quite a long word! And in turn, they can develop into lots of different cells as well So we have the erythrocyte the red blood cell, so one our of fan favorites in Cells at Work. ERYTHRO means red and CYTE, as we said earlier, is a mature cell. The myeloid progenitor cell can also turn into a megakaryocyte which sounds like something out power rangers, doesn’t it? I’ll draw our megakaryocyte here And this is the cell that produces platelets Strictly speaking, platelets themselves are not cells, they’re just fragments broken up from these big megakaryocyte So when the red blood cell and the platelets refer to themselves as sisters, you know, they pretty much are And also just to complete the picture, this myeloid progenitor cell can also turn into our favorite … The neutrophil So they’re kinda all one big happy family So this is our scrape wound, uh it’s much more radical than I expected I mean the whole city, representing the skin, has been damaged, but this kinda fits right? Anyone that’s had a scrape wound or an abrasion before will know that it takes a long time to heal actually you’ll notice some discoloration for awhile, sometimes you’ll be permanently left with some kind of scar, so maybe I underestimated – obviously these guys are very small so even small injuries are gonna have big effects on individual cells There he is, the man! I’m not sure white blood cells quite do this with red blood cells, but you know creative license Okay so in the first episode we had to deal with one bacterium, the streptococcus pneumoniae and in this one we have to deal with a whole bunch, ’cause one of the functions of the skin is to be a physical barrier between the outside world and your bodies, so if that gets broken, then any bacteria that’s just normally happily living on our skin, that doesn’t effect us, can then get under the skin and begin to proliferate and cause an infection like we see all these nasties here And the classic example of a bacterium that normally lives on our skin and doesn’t cause any problems is staphlyococcus aureus and its really well represented here so the staphlyococcus, remember I talked about in the last video means it forms these grape like colonies We can see that the shape they’ve made the bacterium kind of represents that And aureus means gold or yellow-y color that’s obviously why they’ve picked this color because staphlyococcus aureus has this kind of pigment A gold yellow-y pigment that’s part of its defense mechanism that makes it harder for the immune system to break down the bacteria I love that. Its a great sort of visual depiction and explanation of vasoconstriction so when our arteries become more narrow during acute blood loss to stop blood from getting lost Some of the really scary massive bleeds I’ve seen as an emergency doctor, you get an idea of the scale that the body can shut down peripherally when it needs to So the patient would go look very pale and very cold and although that’s what you want your body to do because you want to preserve all the blood for the important organs for a doctor that makes your job more difficult in treating the patient because, you know, we want to get access into the veins to try and give blood and fluids and that’s more difficult when the veins are kind of shutting down So streptococcus pyogenes So pyogenes means puss presumably because this bacteria causes lots of puss when it infects, and pseudomonas! I always wondered what these two bacteria looked like close up When we meet streptococcus pyogenes here its tail is made up of all these little blobs connected together, I think that represents the streptococcus colony formation of this chain that we talked about in the last episode It does make you think, because you have these colonies of bacteria on your skin, that when you do get a trauma and they get in to the body, this exact thing is happening, you know not quite as bad ass and dramatic, but your immune system is doing its job it is fighting these bugs Its a pretty amazing thing to happen just so that all your other cells can carry on living And so that they can carry on making you, you! I’m not quite sure what all these other nasties are, the other bacterium, but maybe we’ll find out in later episodes I’m judging at how much care and attention has gone into this show No doubt they are based on some kind of pathogen – maybe we’ll find out in later episodes I don’t know of any of them that produce these kinds of stick like projections, but let me know in the comments if you do So the ability to communicate between cells totally happens, and you might think how does that happen? Because these neutrophils as we learnt in the first episode are migrating cells, so they can’t really use things like the nervous system to communicate to each other well they use chemical messengers that we call cytokines. so CYTO meaning cells, as we talked about earlier, and KINES meaning kinetic, because these cytokines are when a cell produces them, draw other cells to that area so that would be what would be going on here So the staphylococcus aureus has clearly done her microbiology class, discussing all the immune cells and their kind of rough timelines in fighting infection Aw, so we have the platelets come to the rescue and we see the blood clotting here what we kind of thought we’d see at the beginning of the episode essentially the blood clotting is a load of chemical reactions that turn something that’s soluble in water, fibrinogen, so it can be transported around the body to fibren, something insoluble that forms this kind of net that we can see that covers up the clot Then lots of stuff gets stuck in that net like the platelets and other cells to form a kind of plug and to stop any blood- any more blood from coming out of the blood vessel Aw, we got a little bit of a brewing love story between the red blood cell and the white blood cell I feel bad telling you that… this stuff doesn’t happen And I like her little curved piece of hair she has here I wonder if that’s something relevant or not That’s right, I’ve been reading the comments So they do show the plug that the fibrin sticks everything to in the end So very good! Bravo! Aw man, that’s another fantastic episode I hope you guys enjoyed my thoughts on it I mean the show does such a great job with explaining the medical science Anyway, but if you want me to look at more episodes, then please give this video a thumbs up and a comment and subscribe to the channel as well because then you’ll be notified when I do the next one Just, again, thank you so much for all the support on the first video I was absolutely blown away by the response and I really appreciate it, so I’ll keep doing as much content as I can, so until next time I’ll see you soon

100 thoughts on “Real DOCTOR reacts to CELLS AT WORK! // Episode 2 // “Scrape Wound”

  1. Thank you for these videos! They allow me to not forget what I've learned at medical school even though I dropped it.

  2. I got a cousin who's a former nurse, I showed her the first volume of the manga for this series and she LOVED it, she found it to be a very entertaining way of teaching people about how the human body works in a simple way that would keep them interested.

  3. Teacher:Ok students we are gonna learn how the body works
    Teacher:but we are gonna watch a anime!
    Teachers:but we are gonna watch a doctor react to it

    I don’t mean it in a bad way it’s pretty funny watching a doctor reacting to it XD

  4. I learned more from these videos then I did at school. Can we just watch these videos during science class?

  5. Love these videos. I know it’s been a while since you uploaded them but I wanted to ask if it’s better to put a band aid on a scrap or sore or if it’s better to let it dry out? (Especially if there a staff infection)

  6. Red blood cell and white blood cell mix?

  7. BTW one of the identification tests for pseudomonas include this lemon green color, I believe that's why they made it that color

  8. *Falls and scraps knee*
    Me: ah fuck I’m clumsy
    stares at my knee
    Me: wait is that an anime boy on my knee..

  9. Please react to the once upon a time series cells at work sucks it is just a society of small humans in fantasy costume that encounter aliens and murder them

  10. Staphylococcus aureus is copying the immune system she knows lost in the different kind of cells to destroy them that sounds like immune system but in focus on the pathogens

  11. Its been a while but the curved piece of hair is usually used on "clumsy" or "air-headed" kind of characters.

  12. Cells at work officially made it to the first place for the most scientific, educational anime on earth.

  13. I need to confess something. I’ve watched Cells at Work a few times, and every time I do it makes me cry real tears. It’s just to heart warming to see all the cool little cells working so hard 😭😭😭

  14. The nomenclature and translation is a little misleading but in Japan "oneechan" (big sister) is a generic term one can use for any girl older than the speaker. Just like how in english speaking countries, people use "pops" or "gramps" to any older, middle-aged guy even if they aren't their father. But yeah, it is an interesting coincidence that as cells IRL, they are related.

  15. The main blood cell character in this anime is a scythe blood cell, this is why she get lost every time.

  16. you're awesome DOC! you can be my doctor anytime! your smile alone makes me feel better already, plus its great learning all kinds of medical jargon and anecdotes from your videos! keep it up my man!

  17. I don’t know if this is a right spot to ask, but can someone explain to me what happens when there is blood thinners in your body with Cell’s At Work example? Why you bleed so much and hard to stop bleeding?

  18. 8:40 my first thought was the tail fibers of a bacteriophage virus, but those don't really attack human cells, and its body shape isn't really right. I don't really know, but I'm thinking it may be a protozoan like giardia, or perhaps a fungus like a mucor.

  19. Wonderful insight! I'm only just now getting into this series, and it was these videos of yours that made me interested. 😀

    Little note: in Japan, the term "onee-san," meaning "big sister," is used frequently by younger children to refer to teenage or adult women regardless of whether or not there is a familial relation. This goes pretty much for any word that in English would be family-specific, except for "mother" and "father."

  20. I had methicillin resistant staphylococcus aureus when I was little so when I saw this I just thought
    "We meet again my old foe"

  21. Japanese teachers showing Cells at work is the equivalent to American teachers showing Bill Nye to their class

  22. hy doctor,,,, please react dr stone,, its maybe not like cells at work, but it still about science,,,

  23. I have watch your episode 1 a minute ago and you blow my mind doc! I’ve watch this anime everytime there is an update! So i’m here commenting now! youre so cool! Spoiler alert! I stop the vid at 2:04 because of the bone marrow thing is here also!!! And you just said it in few mins of the episode! You’re so brilliant!!!!! I even understand the show more!! Thank you! I know that I’m sound so dumb about the bone marrow thing but its just so , i don’t know how to said it. But yes , im enjoying this!
    And the big sis thing!! Hahahaha i love it when you take it into a medical level!

  24. 1:05 Yes because these platelets are mature.
    9:53 I also love how she explains it because it’s her evil plan.

  25. 3:20 So what you’re saying is the relationship between the red blood cell character and the white blood cell she likes is incest.

  26. I have a question like my bone crush my lungs like it's so hard to breathe I take slow breath and it goes away

  27. I am currently studying for a big exam on secondary haemostasis. I used to watch this video for recreational purposes. Now it's in my secondary haemostasis playlist.

  28. The stick like bacteria is staff, I think, I don't really know if that's it but I'm assuming with how stick like it looks

  29. I wonder if sperm cells would look like the saiyans (super or not) with their long flagellum tails.

    And the egg cells would be, like, these giant ladies since all eggs are female and are actually the biggest of cells.

    I'm sorry, I just got into this anime and I'm loving it.

  30. The more I learn about white clood cells, the happier I am I have some.

    Perhaps I should bake them a cake to show my appreciation?

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